Withers made 8-of-10 shots from the floor and pulled down nine rebounds, eight off the defensive glass. He scored 12 in the first half. Johnson drained his lone 3-pointer in the first half, forging an 18-18 tie to spark a 17-5 run that pushed the Cardinals into the lead for good.
Prairie View A&M opened the game with a Jeremiah Gambrell 3-pointer and had led by as many as seven until Johnson and Withers scored nine of Louisville's next 17 points on the way to a 41-31 halftime lead.
Withers drove for a layup, was fouled and converted the three-point play, Dre Davis added a 3-pointer and JJ Traynor dunked as Louisville built its lead to 17 points early in the second half and cruised from there.
Davis finished with 12 points. Louisville was 61% from the field (28-of-46) and added 24 more at the free-throw line. The Cardinals blocked three shots, scored 17 points off turnovers and controlled the paint 36-24.
Gambrell finished with 20 points and Faite Williams had six points on 3-of-15 shooting, six rebounds and 11 assists.
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Ga Tech routs No. 20 Clemson 83-65; 3 players score 20
— Georgia Tech returned from a 17-day layoff with one of its most impressive showings of the season, routing No. 20 Clemson 83-65 as three players scored more than 20 points Wednesday night.
Georgia stuns Kentucky with go-ahead basket in final seconds
PJ Horne scores with just over a second remaining to give Georgia a 63-62 win over Kentucky.
Hill scores 20 to lift Longwood over High Point 67-54
— Justin Hill had a season-high 20 points as Longwood got past High Point 67-54 on Wednesday night.