The 15th-ranked Gators announced on Twitter that Egbunu wouldn't return in the second half of Tuesday night's game.
"His knee is bothering him; I know that," coach Mike White said after the game.
White added that Egbunu would have an MRI on the knee Wednesday.
"Hopefully it's not something major. Hopefully, he'll be back soon," White said.
Egbunu had 10 points and four rebounds before going down hard battling for a rebound midway through the half.
The 6-foot-11, 255-pounder came in averaging 7.7 points, 6.7 rebounds and 1.6 blocked shots. Egbunu ranks in the top 10 in the Southeastern Conference in both rebounding and blocked shots.
Information from The Associated Press was used in this report.