Wade, the preseason Big 12 Player of the Year, limped off the floor with 9:18 to go and spent the remainder of the game sitting on the end of the bench. He missed several weeks earlier this season with a right foot injury.
"He had some soreness in his foot all week. He didn't practice. He was in a boot," Weber said. "It's not the same injury as before. He tweaked it. ... We'll just have to see."
Wade, a senior, is averaging 13.9 points, 6.7 rebounds and 2.9 assists per game this season.