7:10 PM, April 15, 2016
- Home Plate Umpire - Ted Barrett
- First Base Umpire - Angel Hernandez
- Second Base Umpire - Lance Barksdale
- Third Base Umpire - Will Little
|1st||Ortiz doubled to deep center, Bogaerts scored.||0||1|
|1st||Shaw doubled to deep center, Ortiz and H. Ramírez scored, Shaw thrown out at third attempting to advance on play.||0||3|
|2nd||Encarnación homered to left (364 feet).||1||3|
|2nd||Betts singled to left, Vázquez scored.||1||4|
|6th||Pedroia reached on infield single to pitcher, Vázquez scored.||1||5|
|7th||Encarnación homered to left (360 feet), Bautista scored.||3||5|
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