The team said Span had a slight headache and was taken out for precautionary reasons.
"I have a headache and I'm a little dizzy," Span said after the game. "It was even scarier on the replay. ... I've never been hit in the head before. ... I'll take some Tylenol tonight and see how I am tomorrow."
Span turned as the pitch was coming inside and the ball appeared to hit him near the back of the helmet before he fell to the ground.
White Sox catcher A.J. Pierzynski immediately called for the trainer. Span remained on the ground for a couple of moments, got up and was helped off the field. He was replaced by Carlos Gomez. Minnesota was leading 4-0.