Butler is available out of the bullpen for Wednesday's game against Pittsburgh.
De La Rosa (1-3, 10.18 ERA) left Tuesday's loss to the Pirates after allowing four runs in three innings. He trotted gingerly to first base after grounding out to lead off the third inning.
Butler, Colorado's first-round pick in 2012 out of Radford, is making his first appearance with the Rockies this season. He is 4-11 with a 6.04 ERA in 19 major league starts over the past two seasons. Butler is 2-0 with a 4.09 ERA in six starts with Albuquerque this season.
The Rockies have a full 40-man roster.