According to the Elias Sports Bureau research, Reyes became the first player in modern major league history to allow multiple home runs as a pitcher and then hit multiple homers in his team's next game.
The only other player in major league history to allow multiple home runs as a pitcher and then hit multiple homers was Hall of Famer Cap Anson. He allowed two homers for the Chicago White Stockings on Aug. 5, 1884, and then hit three home runs on Aug. 6 of that season.
On Tuesday, Reyes was called on to pitch in the eighth inning with his team down 19-1. Making the first pitching appearance of his career, Reyes allowed home runs to Matt Adams and Mark Reynolds, allowing six runs on five hits and two walks. The 25-4 final score marked the worst loss in Mets history.
On Wednesday, the 35-year-old Reyes homered to left field in the fifth inning and to right field in the eighth. His 2-for-3 day improved his season average to .191.
"I didn't even know that," Reyes said to reporters when he was told he made history. "It feels very good, but still, we lost the game after a tough loss. It would've been better if we came out with a win today, but it didn't happen."
ESPN Stats & Information contributed to this report.