Ramirez, a two-time All-Star, exited in the first inning Saturday after fouling off a pitch and underwent an MRI to determine the severity of his condition. The Indians initially termed it "discomfort'' and are expected to update his status Sunday.
"We're really sad because Jose is a happy guy and you guys know that we definitely need him,'' said teammate Franmil Reyes after Cleveland's 4-2 win.
"We need his defense, we need his offense, and he's a great guy. It seemed like he was in a lot of pain. We don't know what's going to happen, but I hope everything is good.''
Indians manager Terry Francona said Ramirez has been dealing with a sore wrist, but the injury occurred in a different area of the joint. The 26-year-old was not wearing a protective brace in the clubhouse and did not speak with the media.
"We took him over to get imaged and we want everybody to see [the results], just to make sure that we get the proper read on it,'' Francona said. "We don't know a ton yet.''
Ramirez is batting .254 with 20 homers and 75 RBIs in 126 games. Utilityman Mike Freeman replaced him and had two hits and an RBI, while infielder Yu Chang was pulled from the lineup at Triple-A Columbus in preparation for a call-up.
"To be honest, I was a little panicked when it happened,'' Freeman said. "You certainly never want to see a guy like Jose get hurt under any circumstances.''
The Associated Press contributed to this report.