Lewis joined Trevor Story as the only players to accomplish the feat. Story connected in his first four games -- totaling six homers in that span -- for Colorado in 2016.
Lewis hit a solo drive off the scoreboard in left field in the fifth inning Thursday in a 11-5 loss to Cincinnati. He doubled and singled earlier in the game.
Called up Tuesday from Double-A Arkansas, Lewis got his first career hit that night when he homered in the fifth inning for Seattle's first hit against the Reds' Trevor Bauer. On Wednesday, he homered in the seventh to end Sonny Gray's no-hit bid.
"When you lose it's a little different, but still cool," Lewis said.
The Associated Press contributed to this report.