The matchup between last year's champion and this year's co-favorite is set to take place on Opening Day at Nationals Park, although Major League Baseball has yet to finalize an official schedule.
The New York Post was first to report the Opening Day matchup.
On Tuesday, after the MLB Players Association signed off on final details of a proposal, the league began to move forward on a 60-game regular season that will run from July 23 or 24 through Sept. 27.
Players and staff members will start traveling to training camp sites -- most of which will be held in home stadiums -- for a July 1 check-in.
Teams will play their four divisional opponents 10 times each, and the other 20 games will be against interleague opponents in the same geographical area (for example, National League West teams vs. American League West teams).
The Opening Day matchup between the Yankees and Nationals could also serve as Gerrit Cole's debut in pinstripes. Cole and the Yankees agreed to a record nine-year, $324 million contract this past winter.