Nationals manager Dave Martinez said the team took five buses for the 45-minute ride to Baltimore so players and staff could space out, with 14 people on each bus.
"It's pretty intense," Strasburg said. "You get on the bus, and you have to wear a face mask the whole time. Then you get in, and basically they temperature screen you. It's kind of tough to get a good temperature reading when it's 100 degrees outside.
"But if you pass that, then you come into the clubhouse, and everybody's kind of sectioned off. So it's just kind of an adjustment that we have to make. But unfortunately, it's kind of challenging to build team chemistry in an environment like this right now."
Strasburg looked fine on the mound, though. The right-hander struck out six, walked none and allowed one earned run.
He said it was "pretty strange" pitching with no fans in the stands.
"It's just what we've got to deal with. I think we're all competitors here, so the game out on the field doesn't really change," Strasburg said.
Howie Kendrick homered, doubled and drove in three runs for the defending champions.