Baldelli said before the game that Buxton could be available off the bench if his condition improves. Buxton was inserted into the game as a pinch runner in the bottom of the eighth inning but was picked off.
Buxton was hit in the helmet by a pitch on Friday and had "mild" concussion symptoms. He was cleared for Game 1 on Tuesday and played the entire game.
The Twins trail the best-of-3 wild-card series against the Houston Astros 1-0 after losing 4-1 Tuesday, their 17th straight postseason defeat.