Monday's game was postponed due to inclement weather at Wrigley Field. The teams will now play two seven-inning games on Tuesday.
Pederson, 29, has been out of the lineup with wrist tendinitis after a slow start to the season at the plate. Pederson is hitting .137 in 51 at-bats heading into Tuesday's games.
He was in the Dodgers organization for a decade before signing a one-year, $7 million deal with the Cubs this past winter.
To make room on the roster, pitcher Keegan Thompson was sent to the Cubs' alternate site.