Cole is 10-6 with a 3.11 ERA in 21 starts. The four-time All-Star was placed on the COVID-19 injured list after testing positive on Aug. 3. Four days earlier, he allowed eight runs in 5⅓ innings in a loss at Tampa Bay.
Speaking before Sunday's game at the Chicago White Sox, Cole described his symptoms as "mild."
"I am feeling good. Ready to go and very much looking forward to it," he said.
"I don't think we'll push the limits by any means because the recovery will be very important."
Cole, 30, is in his second season with the Yankees.