The reigning AL Cy Young winner threw 57 pitches in a minor league start for Double-A Akron on Sunday and had a bullpen session Tuesday.
"He felt pretty good, so we're comfortable with starting him Friday,'' Cleveland interim manager DeMarlo Hale said. "We'll definitely put a pitch count on him. We haven't established that yet, but it won't be too big of a jump from a rehab game in the minors.''
Bieber is 7-4 with a 3.28 ERA in 14 starts. He went 8-1 with a 1.63 ERA in 12 starts during the shortened 2020 season.
The Associated Press contributed to this report.