Lowe connected for a pair of early three-run shots off Jordan Montgomery and then launched a leadoff drive in the seventh inning against Michael King, giving the second baseman a career-high seven RBIs.
Lowe grounded out to first base in the eighth.
Lowe has gone deep in his past three games, and his seven RBIs gave him 99 this season. He increased his career-best total to a team-leading 39 homers with his first three-homer game in the majors.
"It was cool. The first one was probably my favorite one of the day," he said. "The other two were just kind of icing on the cake."
It was his sixth career multihomer game and fourth this year.
"What a day. What a season he's put together. Today was pretty special," Cash said.
Lowe is the fifth Rays player to hit three home runs in a game, joining Evan Longoria (2012 and 2008), Travis d'Arnaud (2019), B.J. Upton (2012) and Jonny Gomes (2005), according to ESPN Stats & Information research.
The Associated Press contributed to this report.