General manager A.J. Preller said earlier this week that the $340 million superstar is expected to miss three months. Tatis led the National League with 42 homers in 2021 and was third in the NL MVP balloting.
It's unclear how the electrifying player broke his wrist, but there were reports in December that he had a motorcycle accident in the Dominican Republic.
Preller said Monday that the team believed the injury occurred early in the offseason but that Tatis didn't start feeling it until he began taking swings about a month ago in preparation for spring training.
Tatis, 23, had a series of injuries to his left shoulder last year and also was on the COVID-19 injury list at one point. He batted .282 with 97 RBI and 25 stolen bases.
Ha-Seong Kim is expected to replace Tatis at shortstop. Kim is entering his second big league season after starring in South Korea.
Tatis signed a $330 million, 14-year contract with the Padres during spring training last year.
The Padres aren't likely to recoup any salary -- or void Tatis' contract -- from games missed due to the injury, sources familiar with the situation told ESPN's Jesse Rogers earlier this week.
In other news, the Padres signed right-hander Nick Martinez to a one-year contract with player options for 2023, 2024 and 2025. To make room on the 40-man roster, left-hander Adrian Morejon was placed on the 60-day injured list.
The 31-year-old Martinez has been pitching in Japan since 2018 and went 10-5 with a 1.62 ERA in 23 games last season for the Fukuoka SoftBank Hawks. He had 146 strikeouts in 149 2/3 innings.
Martinez also won a silver medal last summer with Team USA at the Tokyo Olympics, going 1-1 with a 1.64 ERA over 11 innings in two outings during the tournament. He started the gold-medal game against Japan and gave up one earned run in six innings.
Martinez last pitched in the majors for the Texas Rangers from 2014-17. In four big league seasons, he was 17-30 with a 4.77 ERA in 88 games, including 68 starts.
The Associated Press contributed to this report.