Guerrero, who has a sore left wrist, was in the Blue Jays' initial lineup as the designated hitter before being removed about 2½ hours before first pitch. He made an eighth-inning appearance as a pinch-hitter and was intentionally walked.
Thanks to that appearance, the slugger has missed only one game this season and only two of Toronto's past 269 contests dating to 2020.
Guerrero went 2-for-12 in the first three games of the series in Anaheim, where he spent several summers growing up while his father played for the Angels. Guerrero homered off the left-field pole at Angel Stadium against Shohei Ohtani on Thursday night.
Guerrero's homer off Ohtani was his second in two games after a power drought that lasted through most of May for the slugger, who finished last season tied for the most homers in the majors.
Guerrero is batting .256 this season with nine homers and 24 RBIs.
The Associated Press contributed to this report.