Anderson was activated from the 10-day injured list after being sidelined by a strained right groin. Anderson, who turns 29 on Thursday, got hurt while making a play in the field during a 5-4 victory over the Chicago Cubs on May 29.
The 2019 American League batting champion got two hits in his first game back, leading Chicago to an 8-7 win over Toronto. The White Sox went 8-10 while Anderson was out.
"His stroke is a thing of a beauty," manager Tony La Russa said. "I mean, he can get to anything. He knows his stroke, he stays within himself."
Anderson hit .356 with five homers, 19 RBIs and eight steals in his first 40 games this year. He prepared for his return with four rehab appearances with Triple-A Charlotte, going 5-for-15.
"I was seeing the ball real well, so if I just stay right there where I'm at, just continue to keep pushing, I'll be in a good spot," Anderson said.
To make room for Anderson on the active roster, third baseman Yoan Moncada was placed on the 10-day IL with a strained right hamstring. Moncada left Friday night's 13-3 loss at Houston in the third inning.
The White Sox have been hit hard by injuries this year. Moncada joins an IL list that also includes outfielder Eloy Jimenez, closer Liam Hendriks, catcher Yasmani Grandal and key reliever Aaron Bummer.
"There's many possible explanations ranging from the most insular, to something perhaps we're doing in our training methods, to the most broad in terms of the unique offseason that we all had and the shortened spring training," general manager Rick Hahn said before Chicago's series opener against Toronto.
"This is something that's going on throughout the game. It doesn't mean we aren't each day trying to answer that question in terms of what perhaps are we doing, if not appropriate, what can we do to help stem this tide on the fly."
Moncada also has been sidelined by oblique and quad injuries this year. He appeared to be finding his form when he got hurt, going 7-for-17 with a homer and six RBIs in his past four games.
"It is a very mild strain, not to by any means minimize what he's feeling because it's there and certainly a mild strain has the risk of turning into something more serious if we aren't careful," Hahn said.
Jimenez is slated to restart his rehab with Charlotte on Tuesday. The slugger had surgery April 26 to repair a torn hamstring tendon behind his right knee. His first rehab period in the minors was shut down because of leg soreness.
Hendriks and Grandal also are doing well, according to Hahn, while Bummer is going to be a slower process with his left lat strain. Hendriks is coming back from a right forearm strain, and Grandal has experienced lower back spasms.
Grandal's 10-day IL stint was made retroactive to June 12, and Hahn said he isn't sure whether the veteran catcher is going to need a rehab assignment in the minors.
"Let's see how long this goes," Hahn said. "Again, he's had a really good last three days, so if he has another really good three, let's see where we are at."