Seager got three hits off Shohei Ohtani for the Rangers, but he fouled a pitch off his leg in the fifth inning. Seager delivered an RBI double moments later to put the Rangers up 2-0.
Seager didn't come back out for the sixth, with Marcus Semien moving over to shortstop. Josh H. Smith came in from left field to play second, and Elier Hernandez took Seager's No. 2 spot in the order.
Seager also singled in the first and third innings, emphatically snapping an 0-for-11 drought and a 2-for-20 skid during the Rangers' current road trip.
The Rangers won 2-0.
Seager earned his third All-Star selection and participated in the Home Run Derby earlier this month at Dodger Stadium, his longtime home.
The Associated Press contributed to this report.