The Mets said McNeil had a right thumb laceration and Escobar suffered tightness in his left side that will require an MRI.
McNeil tried to duck under the tag of Philadelphia's Rhys Hoskins on a grounder in the second inning and his head collided with the first baseman's knee.
Escobar was pulled for pinch-hitter Luis Guillorme in the second. In the top half, Escobar had two balls carom off his glove at third for infield hits.
McNeill is hitting .306 with seven homers and 46 RBIs. He had a 13-game hitting streak that ended Friday.
Escobar is hitting .220 with 12 homers and 43 RBIs in his first season with the Mets.