Bautista slipped awkwardly off the mound after delivering a pitch with two outs in the ninth inning, could be seen flexing his hand when he regained his footing and then exited shortly after. Danny Coulombe finished for his second save.
Hyde said that Bautista was still being evaluated.
"When the best closer in the game leaves the game, it's never a good feeling," Hyde said. "Hopefully he's OK tomorrow."
Bautista entered Friday tied for the American League lead in saves with 33, while posting an 8-2 record and 1.49 ERA.