Myers lost Friday night's game and said afterward he has been struggling with tendinitis in his throwing arm this season.
Kazmir has been on the DL with an abdominal strain. Saturday's game will be his first major league start since April 3, 2011. He made one rehabilitation start and allowed five hits and one run -- none earned -- in five innings.
The Indians optioned infielder Cord Phelps to Triple-A Columbus to make room for Kazmir on the roster.
Information from The Associated Press was used in this report.