The 40-year-old Ortiz was hurt on a pitch to Chase Headley in the bottom of the third. Ortiz's left knee appeared to buckle slightly and he came up holding his right elbow. He took his glove in his left hand and slammed it to the ground at the back of the mound. A trainer came out and was looking at the pitcher's right elbow.
Ortiz appeared to be crying as he walked to the dugout.
Ortiz was recalled prior to Saturday's game when Brandon Morrow was placed on the disabled list with a forearm strain.
Ortiz allowed a three-run homer to San Diego starter Edinson Volquez in the second, his first career homer.