The televised card will take place at Tingley Coliseum. UFC officials confirmed the booking to ESPN.com on Tuesday. The Albuquerque Journal first reported the event.
Henderson (20-3) is coming off a narrow split decision over Josh Thomson at a UFC on Fox event in January. Fighting out of Glendale, Ariz., Henderson is 8-1 in the UFC, with all eight wins coming via decision.
A former WEC lightweight champion, Henderson won the UFC belt in February 2012 and defended it three times before losing to Anthony Pettis via first-round armbar in August.
Khabilov (17-1) will enjoy somewhat of a hometown advantage, as he trains out of Jackson's Mixed Martial Arts in Albuquerque. The Russian is on a six-fight win streak, three of which have come in the Octagon.