UFC officials confirmed the 135-pound bout to ESPN.com on Tuesday. The pay-per-view event will take place at Toyota Center.
A former winner of The Ultimate Fighter reality series, Pena (6-2) is 2-0 in the UFC. A devastating knee injury sidelined her for all of 2014, but she looked terrific in her first fight back in April, knocking out Milana Dudieva at 3:59 of the first round.
A Washington native, Pena, 25, was the first female pick on TUF 18. She recorded three consecutive finishes on the show, including a first-round TKO over Jessica Rakoczy in the TUF 18 Finale in November 2013.
Eye (11-3) looks to make a quick turnaround after suffering a unanimous decision loss to Miesha Tate in a No. 1 contender bout last month in Chicago. The loss dropped Eye's official UFC record to 1-2.
Fighting out of Cleveland, Ohio, Eye entered the UFC on a seven-fight winning streak. She defeated Sarah Kaufman in her UFC debut in October 2013, but the result was later changed to a no-contest when Eye tested positive for marijuana metabolites.