The UFC announced the 170-pound bout on Saturday. The event will take place at Movistar Arena in Santiago and is the promotion's first trip to Chile.
Ponzinibbio (26-3), of Argentina, is on a six-fight win streak. The 31-year-old has finished three of those by knockout, including a first-round stoppage over Gunnar Nelson last June.
Usman (12-1) is 7-0 in the UFC. The former collegiate wrestler's most recent performance was a decision win against Emil Meek in January.
Usman now trains out of South Florida.