Officials confirmed the matchup on Tuesday. The UFC 226 pay-per-view event will take place at T-Mobile Arena in Las Vegas. A heavyweight superfight between champion Stipe Miocic and light heavyweight champion Daniel Cormier will headline.
Fighting out of central Florida, Perry has recorded a knockout in all of his wins as a professional.
Medeiros (15-5) is coming off a first-round TKO loss to Donald Cerrone in February. Prior to that loss, Medeiros had won three in a row.
The Hawaiian welterweight has gone the distance only four times in his career.