UFC officials announced the 205-pound main event on Friday. The televised event will take place at Ibirapuera Gymnasium.
Teixeira (27-7) is fresh off a unanimous decision loss to Corey Anderson on July 22 in Germany. The former title challenger has alternated wins and losses in his last six contests.
Manuwa (17-4) is riding back-to-back losses for the first time in his professional MMA career. He wanted to face Teixeira earlier this year, at a UFC Fight Night event in London, but the Brazilian was unavailable. Manuwa ended up taking a rematch against Jan Blachowicz, which he lost by decision.
Both light heavyweight contenders are 38 years old.