Bout agreements have not yet been signed, but both sides have verbally agreed to the matchup, per multiple sources. The strawweight fight will headline UFC Fight Night on ESPN+. The UFC has not yet announced a venue.
Jedrzejczyk (15-3) won the 115-pound championship in 2015 and defended it five consecutive times before suffering a knockout loss to Rose Namajunas in 2017. She lost an immediate rematch to Namajunas in early 2018, but bounced back with a win over Tecia Torres last summer.
Jedrzejczyk moved up to 125 pounds in December to challenge Valentina Shevchenko for the then-vacant flyweight title. Jedrzejczyk lost that bout via unanimous decision, and immediately expressed interest in moving back down to her longtime weight class.
Waterson (17-6) is riding a three-fight win streak. Fighting out of JacksonWink MMA in Albuquerque, New Mexico, the 33-year-old is coming off a decision win against Karolina Kowalkiewicz at UFC Fight Night in March.
The winner of the Oct. 12 matchup would have a strong case for a title shot. Current champion Jessica Andrade, who took the belt from Namajunas in May, is scheduled to defend against Weili Zhang on Aug. 31.