The fights stream on ESPN+, with the main card beginning at 7 p.m. ET and the prelims at 4 p.m.
Lewis (25-8) is coming off a loss to Ciryl Gane in August in a fight for an interim championship. That ended Lewis' four-fight winning streak and sent Gane into a title unification bout with champ Francis Ngannou. Lewis, who is No. 4 in the ESPN heavyweight rankings, has 12 knockouts in the UFC, tying him with Matt Brown for the most ever.
The seventh-ranked Daukaus (12-3 has won five in a row, the last four of which have come in the UFC, all ending in knockout. Eleven of his 12 career wins have been knockouts.
This collision of big, powerful men doesn't seem likely to go the entire five rounds.
How to watch the fights
Stream the main card and prelims on ESPN: Download the ESPN App
Don't have ESPN+? Get it here.
There's also FightCenter, which offers live updates for every UFC card.
Saturday's fight card
ESPN+, 7 p.m. ET
Heavyweight: Derrick Lewis vs. Chris Daukaus
Welterweight: Stephen Thompson vs. Belal Muhammad
Strawweight: Amanda Lemos vs. Angela Hill
Men's bantamweight: Raphael Assunção vs. Ricky Simón
Lightweight: Diego Ferreira vs. Mateusz Gamrot
Men's featherweight: Cub Swanson vs. Darren Elkins
ESPN+, 4 p.m. ET
Middleweight: Dustin Stoltzfus vs. Gerald Meerschaert
Men's bantamweight: Raoni Barcelos vs. Victor Henry
Heavyweight: Justin Tafa vs. Harry Hunsucker
Women's flyweight: Sijara Eubanks vs. Melissa Gatto
Men's featherweight: Charles Jourdain vs. Andre Ewell
Women's bantamweight: Raquel Pennington vs. Macy Chiasson
Heavyweight: Don'Tale Mayes vs. Josh Parisian
Lightweight: Jordan Leavitt vs. Matt Sayles