Tsarukyan (18-2) has won five fights in a row, most recently a second-round TKO of Joel Alvarez in February. He is No. 10 in ESPN's 155-pound rankings.
Gamrot (20-1, 1 NC) has won three straight since suffering his only career defeat in his UFC debut in 2020. His most recent victory was a second-round TKO of Diego Ferreira last December.
Saturday's fights are at the UFC Apex in Las Vegas, with the main card on ESPN and ESPN+ at 10 p.m. ET and prelims on ESPN2 and ESPN+ at 7 p.m.
How to watch the fights
Stream all of the fights on ESPN+: Download the ESPN App
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There's also FightCenter, which offers live updates for every UFC card.
Saturday's UFC fight card
ESPN/ESPN+, 10 p.m. ET
Lightweight: Arman Tsarukyan vs. Mateusz Gamrot
Welterweight: Neil Magny vs. Shavkat Rakhmonov
Heavyweight: Josh Parisian vs. Alan Baudot
Lightweight: Thiago Moises vs. Christos Giagos
Men's bantamweight: Nate Maness vs. Umar Nurmagomedov
Middleweight: Chris Curtis vs. Rodolfo Vieira
ESPN2/ESPN+, 7 p.m. ET
Light heavyweight: Carlos Ulberg vs. Tafon Nchukwi
Men's featherweight: Shayilan Nuerdanbieke vs. TJ Brown
Men's bantamweight: Raulian Paiva vs. Sergey Morozov
Men's flyweight: JP Buys vs. Cody Durden
Men's bantamweight: Brian Kelleher vs. Mario Bautista
Strawweight: Vanessa Demopoulos vs. Jinh Yu Frey
Reed Kuhn's betting tip
"When two strong grapplers collide, it's hard to know if we'll see a back-and-forth wrestling match or if those credentials cancel out and force a standup contest. Tsarukyan boasts the longer UFC résumé, but Gamrot's wrestling background gives him a chance to neutralize the Russian fighter's usual takedown threat. If they spend time trading leather, Gamrot has an accuracy and power edge, even if Tsarukyan can push a superior pace. Five rounds give him plenty of time to work, so we'll see if Gamrot's win over notable (but aging) talent translates into similar performances against future contenders."
For Kuhn's suggested bet on the main event and his advice on other fights on Saturday's card, check out the ESPN+ expert picks and best bets article (link below). It also features analysis by Sayif Saud, coach at Fortis MMA, and ESPN's other betting expert, Ian Parker.