The team said Thursday that the operation is to repair a "core muscle injury." Collison has missed the past seven games with what the team said was a strained right hip flexor.
The Kings said Collison is to meet with Dr. William Meyers on Monday in Philadelphia. Collison will have surgery Tuesday and be re-evaluated in three to six weeks.
In addition to Collison, the Kings also may be without star DeMarcus Cousins at least on Friday as the All-Star center is dealing with a sprained left ankle and a bruised left hip. He is listed as doubtful for the game against the Spurs.
Cousins limped to half court and fell down after turning his ankle in the fourth quarter of Wednesday night's 102-90 win over Memphis. He stayed in the game and showed no effects of the injury.
Collison was injured in Sacramento's loss to the Dallas Mavericks on Feb. 5.
He is averaging a career-high 16.1 points to go with 5.6 assists and 3.2 rebounds. Recently acquired Andre Miller, second-year player Ray McCallum and rookie reserve David Stockton will continue to divide time in Collison's absence.
Information from The Associated Press was used in this report.