Cleveland guard Kyrie Irving, who missed the second half of the Cavs' win over the Detroit Pistons on Monday for precautionary reasons after experiencing tightness in his right hip, played 18 minutes in the first half of a 113-108 overtime victory.
"Overall we'll be very cautious and conscious minutes-wise," Blatt said. "Guys will be on minutes restriction, and we'll give everybody a chance to play and hopefully play hard and well."
James was the only Cleveland starter who did not play Wednesday night, but the other starters sat out the second half.
With the No. 2 seed locked up a week ago and their first-round series already determined against the No. 7-seeded Boston Celtics, James' rest was mapped out ahead of time.
"We looked at the Sunday game in Boston and today's game [for James to rest]," Blatt said. "We talked about it yesterday and just felt it was best for him to rest today too."
James finishes the season with averages of 25.3 points and 6.0 rebounds -- his lowest averages since his rookie season -- while playing the fewest minutes, 36.1 per game, of his career. He also averaged the most assists (7.4) since the final season of his initial stint with Cleveland in 2009-10 but counterbalanced that with a career-high 3.9 turnovers per game.
Washington will open the playoffs at Toronto on Saturday.
The Associated Press contributed to this report.