Harden sprained his ankle in the third quarter of Saturday's loss to the Atlanta Hawks. Harden finished the game with 25 points in 37 minutes.
Harden's status will be determined before practice, and if he fails to participate, his ability to play in Tuesday's game at Oklahoma City would be in question.
The Rockets' leading scorer is one of the NBA's more durable players. Harden leads the league in minutes played (2,637) this season and has missed only one game the past two seasons, and that was due to a suspension.
After Saturday's game, Harden was limping around the locker room.
"The explosiveness wasn't there," he said to The Associated Press. "I felt I was a couple steps behind. ... It's frustrating, especially when you're starting to get in a groove."