It will be the fifth game the All-Star will miss since the Sixers announced on Feb. 20 that he would be out at least a week with left knee soreness.
The Sixers said they would have an update on Embiid's condition before Saturday's game.
On Thursday morning, Sixers coach Brett Brown had hinted that chances were good Embiid would be able to play Saturday, but later in the day backed off that optimism, saying, "We are still learning more."
The Sixers are 3-1 in the games Embiid has missed.
Before the All-Star break, Embiid had played in 54 of Philadelphia's 58 games, though he was dealing with lingering back stiffness and knee soreness before the break. He is averaging career highs in points (27.3), rebounds (13.5), assists (3.5), minutes (33.7) and free throw percentage (81.1).