Harden left Friday's win over the Timberwolves in the third quarter after taking a knee from Karl-Anthony Towns to his thigh. He was limping badly but returned in the fourth quarter, finishing with 12 points and five assists.
This marks the second game Harden has missed this season. He also sat out a loss in New Orleans on Dec. 29.
Harden is averaging 36.1 points to lead the league and has scored 40 or more points 16 times. The Rockets are 14-2 when he does.
The Associated Press contributed to this report.