The Pelicans listed Williamson as out (rest) on its injury report Friday afternoon.
Pelicans coach Alvin Gentry noted that Williamson has not played games on consecutive days at all during his entire rookie season, "and that's the same thing here.''
"We just thought it would be best right now to do it this way, and we'll evaluate tomorrow and see what's going on," Gentry added.
Williamson's minutes have been a hot topic since the seeding games started. He left the NBA bubble in Orlando, Florida, for a family emergency July 16 and returned July 24, quarantining until July 28.
Two days later, he played 15 minutes in the Pelicans' first seeding game against the Utah Jazz. After that, he played 14 minutes against the LA Clippers before ramping it up to 25 minutes in a win over the Memphis Grizzlies on Monday.
Williamson missed 43 games to start the regular season because of surgery on a torn meniscus in his right knee. When he debuted in January, the Pelicans were careful with his minutes and originally said they weren't going to play him in back-to-back games.
But the Pelicans didn't have any back-to-backs before the season went on hiatus in March because of the coronavirus pandemic, and Williamson never missed any games for rest during the regular season -- although he did miss one because of a sprained ankle.
The rest day for Williamson comes at a crucial time for the Pelicans. New Orleans sits 2½ games behind Memphis for the eighth spot in the Western Conference, and two games behind the Portland Trail Blazers for the ninth seed and the right to be in the play-in tournament.
Gentry said he planned to start veteran JJ Redick in a three-guard lineup alongside the usual starting back-court of Jrue Holiday and Lonzo Ball, with Derrick Favors at center and Brandon Ingram at forward.
The Associated Press contributed to this report.