Coach J.B. Bickerstaff confirmed the decision about 90 minutes before tipoff. Garland is listed on the injury report with a sore back. He averages 19.9 points and 8.1 assists.
Garland's absence might mean Caris LeVert could get more playing time after being acquired in a trade with Indiana on Sunday. LeVert scored 42 points in what turned out to be his final home game with Indiana a week ago.
The LeVert trade was the first of three significant moves Pacers president of basketball operations Kevin Pritchard made before Thursday's trade deadline.
The Associated Press contributed to this report.