Gilgeous-Alexander has missed three of Oklahoma City's last four games with right ankle soreness.
Coach Mark Daigneault said Monday night there was no reason to bring Gilgeous-Alexander back given there are so few games left in the season. After Monday night's win in Portland, the Thunder (22-53) have just seven games left.
"Just in terms of what it would take to get him ramped back up and healthy, we're going to run out of time with that one," Daigneault said.
Gilgeous-Alexander averaged 24.5 points, five rebounds and 5.9 assists in 56 games this season.
Daigneault also said forward Darius Bazley won't play the rest of the season because of a fracture in his right knee. Bazley was averaging 10.8 points and 6.3 rebounds.
Rookie Jeremiah Robinson-Earl was set to return against the Blazers after missing 24 games with a third metatarsal fracture in his foot.
The Associated Press contributed to this report.