Jokic became the first player in NBA history with 2,000 points, 1,000 rebounds and 500 assists in a season. He had 35 points, 16 rebounds, six assists and five steals Thursday evening.
"Dude is really great at basketball," teammate Bones Hyland said.
After having to retreat to the bench twice to stop the bleeding, Jokic donned a red headband for the remainder of the game as he helped the Nuggets (48-33) overcome a shaky start to avoid a season sweep at the hands of the Grizzlies.
"The MVP isn't even a competition," Nuggets coach Michael Malone declared afterward. "There's other great players. I'm not saying they're not great players. But what Nikola Jokic has done this year -- with this team, everything we've had to go through -- is just incredible.
"He was good last year, and he's even better this year."
Despite missing stars Jamal Murray and Michael Porter Jr., the Nuggets clinched a top-six spot in the Western Conference playoffs and avoided the four-team play-in thanks to another outstanding performance from the reigning MVP.
They can still win the Northwest Division with a victory Sunday night against the Los Angeles Lakers and two losses by the Utah Jazz (48-32), who finish up against the Phoenix Suns and Portland Trail Blazers. Denver's victory also locked the Minnesota Timberwolves into the play-in.
Aaron Gordon added 22 points for the Nuggets.
Desmond Bane had 14 points for the Grizzlies, who were coming off an overtime loss at Utah on Wednesday night after having already captured the first division title in their history along with securing the second seed in the West.
"I think we've been playing good basketball, even the other night against Utah. Tonight, we just didn't have it,'' Grizzlies coach Taylor Jenkins said.
Jokic was the biggest reason.
"We threw a lot at him,'' Jenkins said. "He's the MVP for a reason. He's nearly impossible to guard. He's going to beat you from inside, outside, playmaking. He played at a really high level tonight.''
The Grizzlies are hopeful of getting All-Star guard Ja Morant back this weekend from a right knee injury that has sidelined him since March 18.
Malone said he was concerned after seeing Jokic bloodied in such a pivotal game for Denver.
"My first thought was Steve Nash in that playoff series and they couldn't stop the bleeding," Malone said. "And I'm saying, 'Of all games, Nikola gets a very nonmalicious elbow, an inadvertent elbow to the head, and he's bleeding.'
"I'm saying, 'Not tonight.'"
Malone said he implored his trainers to do whatever they could to staunch the flow of blood.
"Like, get a staple gun out here," Malone said. "And it finally stopped, and Nikola put on another MVP performance."
Jokic said he isn't going to keep wearing the headband, however. He'll leave that look to LeBron James.
"No, I look great,'' Jokic said. "I cannot let you guys see me twice like that."
Jokic agreed he has had a better season than last year, but he said there are 20 superstars in this league and that he isn't himself lobbying for another MVP award.
"If that's enough, it's enough," he said. "It not, you cannot control that.''
Jokic got a game ball from the Nuggets as a keepsake of his historic night, but he joked the trainers would probably sell his blood-soaked headband on eBay.
The Associated Press contributed to this story.