Coach Steve Clifford said it is too early to know how much time Ball will miss after spraining the ankle for a second time in a 125-113 loss to the Indiana Pacers on Wednesday night.
Ball first injured his ankle on Oct. 10 during a preseason game against the Washington Wizards when he stepped on an opposing player's foot. That caused him to miss more than a month of action, including the first 13 games of the regular season.
Ball had returned over the weekend and played three games before rolling it again when he stepped on a fan's foot as he was attempting to save a ball from going out of bounds in the fourth quarter.
Ball grimaced in pain and immediately limped to the training room and did not return.