James, who passed Kareem Abdul-Jabbar as the NBA's all-time leading scorer on Tuesday, still participated in a pregame on-court ceremony to commemorate the record.
It was the 12th missed game this season for the 20-year veteran.
While L.A. held James out for rest, he remained on the active roster for the night. With a flurry of moves leading up to Thursday's trade deadline, the Lakers will have only nine available players outside of James.
L.A. enters the game 25-30, three losses back from the LA Clippers for the No. 6 seed in the Western Conference.