EAST RUTHERFORD, N.J. -- New York Giants cornerback Prince Amukamara left in the second quarter of Monday night's 40-24 loss to the Indianapolis Colts with a biceps injury and did not return to the game.
Giants coach Tom Coughlin wasn't optimistic about Amukamara's return this season.
"Normally that's surgery," Coughlin said.
It was a big loss for a Giants secondary that was already short-handed due to injury and was facing the league's No. 1 passing offense in the Colts.
"There is a lot of concern," Coughlin said. "We've lost a player or two in each game, it seems like. That's not a good one. Prince was playing well. He did a very nice job tonight, and that was a blow to lose him."
Nickel cornerbacks Walter Thurmond and Trumaine McBride already have been lost for the season, and Dominique Rodgers-Cromartie is severely limited due to leg and back injuries and was in and out of the Monday night game.
At this point, that leaves Zack Bowman, Chandler Fenner and Jayron Hosley as the only fully healthy cornerbacks on the Giants' roster, although they can supplement it somewhat if they use three safeties and move Stevie Brown or Antrel Rolle to the nickel position.
Meanwhile, starting left guard Weston Richburg was carted off with a right ankle injury and was on crutches with a boot on his foot after the game.
Coughlin said he wasn't sure of Richburg's status.
"I don't know," Coughlin said. "I haven't heard anything on that. He had X-rays. I would be foolish to say anything about it until I hear."
Receiver Preston Parker was wearing a boot, too, on his left foot after the game. His status also was uncertain.
ESPNNewYork.com's Kieran Darcy contributed to this report.