EAST RUTHERFORD, N.J. -- New York Giants running back Brandon Jacobs, defensive end Justin Tuck, right guard Chris Snee, fullback Henry Hynoski and long-snapper Zak DeOssie all missed practice for a second straight day with various injuries.
Jacobs is nursing a mild MCL sprain that caused him to miss Sunday's game against Seattle. He did not speak to reporters Thursday, his usual day to talk.
Head coach Tom Coughlin said there's still some swelling in Jacobs' knee. Coughlin thought there would be an "outside shot" that Jacobs would practice Thursday, but it didn't materialize.
Asked if Jacobs could practice this week, Coughlin responded, "I hope so."
"In the beginning I was not thinking that it was gonna be an issue like this, but he has had swelling, so they've tried to keep him off his feet so he doesn't swell," Coughlin said. "He gets treatment pretty much all day long, but so far that hasn't completely taken care of the swelling."
Tuck, who is battling neck and groin injuries, rode the bike during practice. Tuck has missed three of the Giants' first five games this season and is considering sitting out through the team's Week 7 bye.
"This process is frustrating, no question," Tuck said.
Tuck did some running on Thursday, but said his status for Sunday's game against the Bills is "unknown." He characterized himself as "day to day" and "hopeful."
If he does play, Tuck said he would be on a play counter in order to limit his snaps.
He said his groin is bothering him more than his neck at this point, but he added that he hasn't had any physical contact in weeks.
The defensive end suffered a setback last Thursday, something he says maybe wouldn't have happened if he didn't rush back, so he's taking things slow this time around to avoid another one.
"I came back too early, had a setback, and I'm being punished right now," Tuck said. "I had sat out the last three weeks like people were telling me to, maybe I'd be playing this week regardless."
Tuck will have to be cleared by doctors before he can play.
Snee and DeOssie are both recovering from concussions they suffered against the Seahawks.
"He's getting a little better each day, but he still has his moments," Coughlin said of Snee.
If Snee can't play, Kevin Boothe would be the likely candidate to start in his place.
As for DeOssie, Coughlin said, "We'll see what happens."
Jim Cordle served as the backup long-snapper last Sunday, and could take DeOssie's place if he can't go.
Hynoski has a neck burner, which he sustained against the Seahawks last Sunday.
Defensive end Osi Umenyiora, who is recovering from his knee operation, returned to practice Thursday after missing Wedensday's session.
Center David Baas and linebacker Michael Boley were both on the practice field Thursday after being limited Wednesday. Baas missed the game against the Seahawks with a burner, and Boley has been dealing with a knee issue.
Rookie cornerback Prince Amukamara, still recovering from foot surgery, did individual running drills on the side.
Mike Mazzeo is a frequent contributor to ESPNNewYork.com.