Ross missed practice this week with a back injury and had already been ruled out of Sunday's game against the Philadelphia Eagles after starting the past two contests in place of the injured Corey Webster.
In corresponding roster moves, the Giants activated safety Will Hill from the suspended list and signed cornerback Charles James from their practice squad. New York also waived offensive lineman Dallas Reynolds, who was signed earlier in the week due to injuries on the Giants' offensive line.
Putting Ross, and not inured center David Baas, on IR and waiving Reynolds indicates that the Giants expect Baas to make a recovery from the neck injury that will force him to miss his second straight game Sunday. The Giants placed right guard Chris Snee on season-ending injured reserve Friday when they acquired linebacker Jon Beason in a trade with the Carolina Panthers.
Hill, who missed the first four games of the season on a drug suspension, returns to a depleted safety corps that has been without starter Stevie Brown since he tore his ACL in a preseason game. The Giants had only two safeties active for last week's game in Kansas City.
James was one of the Giants' final training camp cuts after a strong preseason as a punt returner. But with Webster doubtful, Ross done and Jayron Hosley out for Sunday's game, James could very well see playing time at cornerback.