Wilson and Sharpe announced their intentions Tuesday on Twitter, one day after 20th-ranked Florida beat No. 21 Iowa 30-3 in the Outback Bowl.
Gators center Cameron Dillard, who started eight games this season and 19 over the past two seasons, also announced he intends to transfer. As a graduate transfer, Dillard will be able to play elsewhere right away.
Wilson had three interceptions this season. He is expected to one of the first cornerbacks taken during the NFL draft in late April.
Sharpe thanked the school "for everything they've done for me and three years of life-changing experiences."
Just a few minutes earlier, Florida defensive back Duke Dawson announced he will return for his senior season. Dawson called it "one of the toughest decisions in my life at this point."