Predicting NFL Week 1 upset picks, fantasy football sleepers and flops, plus what we're hearing around the league

We've waited seven long months, but Week 1 of the 2021 NFL season is finally here. It all kicks off with an exciting Thursday night opener between the Dallas Cowboys and Tampa Bay Buccaneers, but 16 games are on tap this week. We will get our first sense of how the season might play out and which teams look ready for big years, so we asked ESPN insiders Dan Graziano and Jeremy Fowler for some insight into the first week's slate.

What are the best upset picks out of the gate, and why might a pair of Super Bowl contenders get off to a rough start? Who are the must-start sleepers in fantasy, and who might be a Week 1 big-name flop? What can we actually learn from just one week of games, and what should we be watching for? What will happen over the course of the year? Graziano and Fowler get into all of it, and they cap it off with everything else they've heard this week, from trade chatter to injury statuses.

Let's get started with our top upset alerts, but you can also jump to other big questions for Week 1.

Jump to:
Upsets | Season predictions
Fantasy starts | Fantasy flops
What to watch for | Emptying the notebook

What's your top upset pick for Week 1?