Predicting NFL Week 4 upset picks, fantasy football sleepers and flops, plus buzz and notes around the league

We're heading into Week 4 of the 2021 NFL season, and we're already seeing a few early trends that need to be monitored closely. We asked ESPN insiders Dan Graziano and Jeremy Fowler for their insight into this week's slate. They discuss everything from which team is dealing with the most impactful injury to teams and players that have changed their minds since the season has started.

Graziano and Fowler also share their favorite upset picks for Week 4, including a team seeking its first victory of the season. And for fantasy managers looking to make all the right moves, they name fringe players to start and point out potential flops to avoid. They get into all of it and cap it off by emptying their notebooks with everything else they've heard this week, including what's next for Richard Sherman, some insight on the Bills' running back situation, Steelers' T.J. Watt's status and, yes, a look into what's happening with Chicago's quarterback situation.

Let's get started with the upset picks of the week, but you can also jump to other big questions for Week 4.

Jump to:
Upsets | Surprises
Impactful injuries | Fantasy starts
Fantasy flops | Emptying the notebook

What's your top upset pick for Week 4?