Predicting NFL Week 5 upset picks, fantasy football sleepers and flops, plus buzz and notes around the league

We're heading into Week 5 of the 2021 NFL season, and with just one 4-0 team, we're seeing a lot of parity. We asked ESPN insiders Dan Graziano and Jeremy Fowler for some insight into this week's slate. Which rookies have left the biggest impression so far this season? Which teams with a 1-3 record have the best chance to make a playoff run? And what about that Sunday night showdown between the Chiefs and the Bills?

Our experts share their favorite upset picks for Week 5, including an unsuspecting team who is 3-1 to start the year. And for fantasy managers looking to make all the right moves, Graziano and Fowler name must-start sleepers and point out potential fantasy flops of the week. They get into all of it, emptying their notebooks with everything they've heard this week, including injury updates for the Bears and 49ers, and what the Jaguars' team owner's statement on Urban Meyer means for the team.

Let's get started with the upset picks of the week, but you can also jump to other big questions for Week 5.

Jump to:
Upsets | 1-3 teams
Fantasy flops | Fantasy starts
Impressive rookies | More notes

What's your top upset pick for Week 5?